It seems like the folks at Prometheus Fusion Perfection have matured their equipment and operations to the point of being able to run on a fairly repeatable basis. Right now they are working on a Symmetry test of their polywell. I posted a link to an example design/analysis using R that would allow a basic response surface for the device to be estimated (script embedded below the fold). It uses AlgDesign for the blocking by shot, and lme4 to fit a model that includes a random effect to account for shot-to-shot variation.
Here's a good thread on the differences between nlme:lme and lme4:lmer.
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